In most database products, you can't update multiple tables in a single statement, so you'll have to run separate statements in jOOQ. By "single execute", you probably mean you want to have the experience of a single operation in the jOOQ API (irrespective of how many statements are being generated), but that also doesn't exist.
So, you just run multiple statements:
ctx.update(A)
.set(A.X, someValue)
.where(someCondition)
.execute();
ctx.update(B)
.set(B.Y, someValue)
.where(someCondition)
.execute();
If, for some reason, the single round trip to the server is important to you, you can use the procedural language API in jOOQ to wrap the above in an anonymous block:
ctx.begin(
update(A)
.set(A.X, someValue)
.where(someCondition),
update(B)
.set(B.Y, someValue)
.where(someCondition)
).execute();
Or, you can batch the statements, but they will be separate statements.