In VS2022 when debugging: Unable to set the next statement. Class not registered

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I am debugging a .NET C# solution in VS2022. Whenever I attempt to set the next statement I get the error message

Unable to set the next statement. Class not registered.

I am also not able to hot-reload either when I make a change. If I make the slightest change (even just adding some whitespace) and the click on the hot reload button I get the message

This source file has changed. It no longer matches the version of the file used to build the application being debugged.

I appreciate that the second statement is more common but I thought the point of hot-reload was that it recognised that the file had changed and would reload it!

I have found links for the first message but never in combination with the class not being registered.

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