I updated to google chrome Version 98.0.4758.102 (Official Build) (64-bit) and I have an aspx, inside an Iframe that loads another aspx where I get the pdf file to base64 string, then send the bytes to a response with other headers, and that response goes to the browser.
Let me know of any information I can add here as I'm deciphering the code myself too and I don't know which issues are common when updating chrome.
It is fair to say that it works on IE, Edge, Firefox, Brave.