Maybe you could could use itertools.combinations_with_replacement, itertools.permutations along with collections.Counter:
>>> from collections import Counter
>>> from itertools import combinations_with_replacement, permutations
>>>
>>> def is_valid_combination(comb: tuple) -> bool:
... digit_counts = Counter(comb)
... return digit_counts[1] >= 1 and \
... digit_counts[2] >= 1 and \
... digit_counts[3] >= 1
...
>>> choices = [1, 2, 3]
>>> valid_combinations = [
... c for c in combinations_with_replacement(choices, r=5)
... if is_valid_combination(c)
... ]
>>>
>>> valid_combinations
[(1, 1, 1, 2, 3), (1, 1, 2, 2, 3), (1, 1, 2, 3, 3), (1, 2, 2, 2, 3), (1, 2, 2, 3, 3), (1, 2, 3, 3, 3)]
>>>
>>> all_permutations_of_valid_combinations = {
... p
... for c in valid_combinations for p in permutations(c)
... }
>>>
>>> all_permutations_of_valid_combinations
{(2, 1, 3, 1, 2), (2, 1, 3, 2, 1), (3, 3, 2, 1, 3), (1, 2, 3, 2, 3), (1, 2, 1, 3, 1), (3, 1, 2, 3, 2), (3, 3, 3, 2, 1), (3, 2, 2, 1, 1), (1, 2, 2, 3, 1), (1, 3, 2, 2, 3), (1, 3, 2, 3, 2), (1, 2, 1, 1, 3), (3, 1, 3, 3, 2), (3, 1, 1, 2, 3), (2, 1, 3, 2, 3), (1, 2, 2, 1, 3), (1, 2, 1, 3, 3), (2, 3, 3, 1, 2), (2, 3, 3, 2, 1), (3, 3, 1, 2, 1), (3, 2, 3, 2, 1), (1, 2, 2, 3, 3), (3, 2, 1, 1, 1), (2, 2, 1, 3, 1), (2, 3, 1, 1, 1), (1, 3, 1, 2, 3), (3, 3, 1, 1, 2), (3, 2, 3, 1, 2), (2, 1, 2, 3, 1), (2, 2, 1, 1, 3), (3, 2, 1, 3, 1), (2, 3, 1, 3, 1), (1, 1, 3, 2, 1), (2, 3, 2, 1, 2), (2, 3, 2, 2, 1), (2, 1, 2, 1, 3), (3, 2, 1, 1, 3), (2, 2, 1, 3, 3), (2, 3, 1, 1, 3), (2, 3, 1, 2, 2), (3, 2, 3, 3, 1), (1, 1, 3, 1, 2), (2, 1, 2, 3, 3), (3, 3, 2, 2, 1), (3, 1, 2, 1, 2), (3, 2, 1, 3, 3), (3, 1, 2, 2, 1), (2, 3, 1, 3, 3), (1, 1, 3, 2, 3), (3, 3, 3, 1, 2), (1, 2, 3, 1, 1), (1, 1, 3, 3, 2), (3, 1, 3, 1, 2), (2, 3, 2, 3, 1), (1, 3, 2, 1, 1), (2, 1, 3, 3, 1), (3, 2, 2, 3, 1), (3, 1, 2, 2, 3), (1, 3, 2, 2, 2), (1, 2, 3, 1, 3), (1, 3, 2, 3, 1), (3, 2, 2, 1, 3), (2, 2, 3, 2, 1), (3, 1, 1, 2, 2), (1, 1, 2, 2, 3), (2, 1, 3, 2, 2), (1, 3, 3, 2, 2), (3, 3, 1, 3, 2), (2, 1, 1, 3, 1), (1, 3, 2, 1, 3), (2, 1, 3, 3, 3), (3, 1, 3, 2, 2), (2, 2, 3, 1, 2), (1, 1, 2, 3, 1), (3, 2, 1, 2, 2), (1, 2, 2, 3, 2), (3, 3, 1, 2, 3), (1, 3, 2, 3, 3), (1, 2, 1, 2, 3), (3, 2, 3, 1, 1), (1, 3, 1, 2, 2), (1, 2, 2, 2, 3), (2, 1, 1, 3, 3), (3, 1, 1, 3, 2), (1, 1, 2, 3, 3), (1, 3, 3, 3, 2), (2, 3, 2, 1, 1), (2, 2, 1, 2, 3), (2, 2, 1, 3, 2), (1, 2, 3, 3, 1), (3, 2, 3, 1, 3), (2, 3, 1, 2, 1), (2, 1, 3, 1, 1), (3, 3, 2, 1, 2), (1, 2, 3, 2, 2), (1, 3, 1, 3, 2), (3, 1, 2, 3, 1), (2, 2, 2, 3, 1), (2, 1, 2, 2, 3), (1, 2, 3, 3, 3), (2, 3, 1, 2, 3), (2, 1, 3, 1, 3), (3, 2, 2, 2, 1), (1, 2, 1, 3, 2), (2, 3, 3, 1, 1), (3, 1, 2, 3, 3), (3, 2, 2, 1, 2), (3, 1, 1, 2, 1), (1, 3, 3, 2, 1), (2, 3, 3, 3, 1), (2, 1, 1, 1, 3), (1, 3, 2, 1, 2), (2, 1, 3, 3, 2), (1, 1, 1, 2, 3), (3, 1, 3, 2, 1), (1, 1, 1, 3, 2), (2, 2, 3, 1, 1), (3, 1, 1, 1, 2), (1, 1, 2, 1, 3), (1, 3, 3, 1, 2), (3, 2, 1, 2, 1), (2, 3, 3, 1, 3), (3, 3, 1, 2, 2), (2, 2, 3, 3, 1), (1, 3, 1, 2, 1), (1, 3, 3, 2, 3), (3, 2, 1, 1, 2), (2, 1, 1, 3, 2), (2, 3, 1, 1, 2), (3, 1, 3, 2, 3), (2, 2, 3, 1, 3), (1, 3, 1, 1, 2), (1, 1, 2, 3, 2), (2, 1, 2, 3, 2), (3, 2, 1, 2, 3), (3, 1, 2, 1, 1), (3, 2, 1, 3, 2), (2, 1, 1, 2, 3), (2, 3, 1, 3, 2), (1, 1, 3, 2, 2), (2, 3, 2, 1, 3), (3, 3, 2, 3, 1), (3, 3, 2, 1, 1), (1, 2, 3, 2, 1), (3, 1, 2, 1, 3), (2, 2, 2, 1, 3), (3, 1, 2, 2, 2), (1, 3, 2, 2, 1), (1, 2, 3, 1, 2), (1, 2, 3, 3, 2)}