You can view the array as series of 20x20 blocks, of which you want to keep the upper-left 5x5 portion. Let's say you have
keep = 5
discard = 15
This only works if
assert all(s % (keep + discard) == 0 for s in arr.shape)
First compute the shape of the view and use it:
block = keep + discard
shape1 = (arr.shape[0] // block, block, arr.shape[1] // block, block)
view = arr.reshape(shape1)[:, :keep, :, :keep]
The following operation will create a copy of the data because the view creates a non-contiguous buffer:
shape2 = (shape1[0] * keep, shape1[2] * keep)
result = view.reshape(shape2)
You can compute shape1 and shape2 in a more general manner with something like
shape1 = tuple(
np.stack((np.array(arr.shape) // block,
np.full(arr.ndim, block)), -1).ravel())
shape2 = tuple(np.array(shape1[::2]) * keep)
I would recommend packaging this into a function.