The content of the odbcinst.ini file is :
# Example driver definitions
# Driver from the postgresql-odbc package
# Setup from the unixODBC package
[PostgreSQL]
Description = ODBC for PostgreSQL
Driver = /usr/lib/psqlodbcw.so
Setup = /usr/lib/libodbcpsqlS.so
Driver64 = /usr/lib64/psqlodbcw.so
Setup64 = /usr/lib64/libodbcpsqlS.so
FileUsage = 1
# Driver from the mysql-connector-odbc package
# Setup from the unixODBC package
[MySQL]
Description = ODBC for MySQL
Driver = /usr/lib/libmyodbc5.so
Setup = /usr/lib/libodbcmyS.so
Driver64 = /usr/lib64/libmyodbc5.so
Setup64 = /usr/lib64/libodbcmyS.so
FileUsage = 1
Here I want to modify only Driver64 line under [Postgresql].
I tried to do it using sed command
sed -i 's/Driver64.*/Driver64=/usr/some/path/'
But this will change every instance of Driver64. And it might not help if [postgresql] block is placed somewhere else.