I've always wondered if there is a difference if you build a PLC project in the Debug or Release configuration. I don't think there is since the .compileinfo file in the _CompileInfo folder is the same size and it has the same filename (some hash I guess). Also when I log in after building with the other configuration, I do not get the prompt if I want to log in with online changes.
Does anyone know if the build configuration has an influence on the compiled code?