How to properly use the asynchronous libusb?

I worked on the synchronous libusb in my Qt project with good results and now I need the asynchronous features of this library. I understood reading here, here and here that, after I've registered my callback function using the libusb_fill_control_transfer and submitted a transfer with libusb_submit_transfer , I need to "keep live" the libusb_handle_events_completed inside a while loop to get the transfer related events since the libusb doesn't have its own thread. for example you can read a code like this

libusb_fill_control_transfer(transfer, dev, buffer, cb, &completed, 1000);
libusb_submit_transfer(transfer);
while (!completed) {
    libusb_handle_events_completed(ctx, &completed);
}

Now if I want read a packet that I don't know when it occurs, I think that goes against the asynchronous nature submit a read and wait in the while with libusb_handle_events_completed until the event is triggered.

Then, do I need to create a separate thread within the libusb_handle_events_completed in an infinite while loop?

Can anyone, with experience in the asynchronous features of libusb library, give some suggestions on the right approach to handle the transfer events?