In most terminal emulators Middle Mouse Button will paste from the X Windows primary selection. In tmux with mouse mode enabled (set -g mouse on) Middle Mouse Button no longer pastes from the primary selection because the mouse click is captured by tmux rather than by the terminal emulator. To paste you have to do Shift + Middle Mouse Button to pass the click through to the terminal emulator.
How can I make Middle Mouse Button paste without having to hold down Shift, even when mouse mode is enabled?