ggplot2 prefers data frames, and for something like this, frames in a long format.
Here's a basic way to do it.
First, reproducible random data.
set.seed(42)
myseq<-seq(from = 1, to = 99, by = 5)
mtx <- array(rnorm(880,0,1) ,c(4,11,length(myseq)))
mtx[1,1:4,1:4]
# [,1] [,2] [,3] [,4]
# [1,] 1.3709584 -1.3682810 0.9333463 6.288407e-05
# [2,] 0.4042683 -0.4314462 0.6503486 -1.173196e-01
# [3,] 2.0184237 1.5757275 -1.1317387 -8.610730e-02
# [4,] -1.3888607 0.6792888 1.2009654 -4.138688e-01
From here, we can basically convert this 3D array into a four column data.frame, where three of the columns indicate the axes, and the fourth is the actual value.
melted_mtx <- reshape2::melt(mtx[1,,,drop=FALSE])
str(melted_mtx, vec.len=15)
# 'data.frame': 220 obs. of 4 variables:
# $ Var1 : int 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ...
# $ Var2 : int 1 2 3 4 5 6 7 8 9 10 11 1 2 3 4 5 6 7 8 9 10 11 1 2 3 4 5 6 7 8 9 10 11 1 2 3 4 5 ...
# $ Var3 : int 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 3 4 4 4 4 4 ...
# $ value: num 1.371 0.404 2.018 -1.389 -0.284 -0.307 1.895 0.46 1.035 -0.784 0.206 -1.368 -0.431 1.576 0.679 -0.367 -0.727 0.921 0.624 ...
Since you want to plot myseq on the x-axis, we can do a replacement with that. It's in the third variable here, Var3. I'll verify that it is the correct length and then do the replacement:
lapply(melted_mtx[-4], table)
# $Var1
# 1
# 220
# $Var2
# 1 2 3 4 5 6 7 8 9 10 11
# 20 20 20 20 20 20 20 20 20 20 20
# $Var3
# 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
# 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
melted_mtx$Var3 <- myseq[melted_mtx$Var3]
lapply(melted_mtx[-4], table)
# $Var1
# 1
# 220
# $Var2
# 1 2 3 4 5 6 7 8 9 10 11
# 20 20 20 20 20 20 20 20 20 20 20
# $Var3
# 1 6 11 16 21 26 31 36 41 46 51 56 61 66 71 76 81 86 91 96
# 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
We can use that and feed it to ggplot2 rather directly.
library(ggplot2)
ggplot(melted_mtx, aes(Var3, value, group = Var2, color = factor(Var2))) +
geom_line()

The base graphics plot of that (your code) renders:

which, margins and colors aside, is effectively the same plot. There is plenty of beautification that can be done, including legend labels, axes, etc.
Above, I only melted the first plane of the array. If you did the whole array, then it'd look like this:
melted_mtx <- reshape2::melt(mtx)
melted_mtx$Var3 <- myseq[melted_mtx$Var3]
ggplot(melted_mtx, aes(Var3, value, group = interaction(Var1, Var2),
color = interaction(Var1, Var2))) +
geom_line()

This is a bit complex, clearly, but with the use of interaction, you can group by multiple variables. Grouping is required here, since without it ggplot2 will try to connect all of the points in a single line, generally not useful. Usually one can get away with using just color= to suggest the groups, but I often include both group= and color= in case I later change how colors/linetypes/shapes/... are defined, and groups are accidentally changed.