You can continue like you have, simply defining more coordinateX variables. However, this will eventually become a problem. Imagine having hundreds of separate variables!
A nicer way would be to use a Python list to hold all the co-ordinates:
point_list = [ (250, 0), (500, 250) ]
(There's lots of online tutorials about Python lists.)
Each element can be accessed (or assigned) by using square-bracket notation with an index-number (starting at zero), so point_list[0] is (250, 0); and point_list[1] is (500, 250). To get the individual x,y parts of each co-ordinate, you can add another pair of square brackets, or get all the parts at once:
first_x = points_list[0][0] # 250
first_y = points_list[0][1] # 0
first_x, first_y = points_list[0] # 250, 0
Lists can hold huge amounts of points, for example, a simple 3-point star:
point_list = [ (148, 170), (200, 20), (252, 170), (356, 290), (200, 260), (44, 290) ]
The other nice thing about keeping them in a list is that you can use the PyGame function pygame.draw.polygon() to simply draw them to the screen.
pygame.draw.polygon( window, YELLOW, point_list, 1 )
Or you can "iterate" through the list, drawing the lines:
for i in range( len( points_list ) - 1 ):
pygame.draw.line( screen, white, points_list[i], points_list[i+1], 5 )
Note that I looped with the length-of-list len() minus one, so we didn't go over the end of the list when referencing [i+1].
Here's a quick example I wrote using the above ideas:

Code:
import pygame
# Window size
WINDOW_WIDTH = 400
WINDOW_HEIGHT = 400
DARK_BLUE = ( 3, 5, 54)
STARRY = ( 230, 255, 80 )
### initialisation
pygame.init()
window = pygame.display.set_mode( ( WINDOW_WIDTH, WINDOW_HEIGHT ) )
pygame.display.set_caption("Star")
# Define a star
centre_coord = ( WINDOW_WIDTH//2, WINDOW_HEIGHT//2 )
star_points = [ (165, 151), (200, 20), (235, 151), (371, 144), (257, 219),
(306, 346), (200, 260), (94, 346), (143, 219), (29, 144) ]
### Main Loop
clock = pygame.time.Clock()
done = False
while not done:
# Handle user-input
for event in pygame.event.get():
if ( event.type == pygame.QUIT ):
done = True
# Re-draw the window
window.fill( DARK_BLUE ) # background fill
pygame.draw.polygon( window, STARRY, star_points ) # Draw the star
pygame.display.flip() # Update the display
# Clamp FPS
clock.tick_busy_loop(60)
pygame.quit()
Or perhaps a 16-point star of 32 co-ordinates:
point_list = [ (173, 63), (200, 20), (227, 63), (269, 34), (278, 84),
(327, 73), (316, 122), (366, 131), (337, 173), (380, 200),
(337, 227), (366, 269), (316, 278), (327, 327), (278, 316),
(269, 366), (227, 337), (200, 380), (173, 337), (131, 366),
(122, 316), (73, 327), (84, 278), (34, 269), (63, 227),
(20, 200), (63, 173), (34, 131), (84, 122), (73, 73),
(122, 84), (131, 34) ]