This question is different from "Why do we ignore coefficients in Big-O notation".
When measuring time complexity we usually use Big-O notations which ignore the coefficients and non-dominant elements. However, don't 2N+C and N+C instructions result in significant differences in execution time, especially when the problem size grows very large? The former will take twice more time than the latter, which could be two weeks compared with one week in real-world large scale computation.
Examples include quicksort vs. other O(NlogN) sort algorithms and the trivial O(N^3) matrix multiplication vs. Strassen's algorithm (which can be slower because the leading coefficient is much larger even with less exponent)