Proper way of using db connections? (Python + pyodbc)

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I am currently building a REST API using Python and Flask. Most endpoints require some type of interaction with a SQL database (SQL Server, using pyodbc). What is the best way of going around this.

  • Should I open a single connection (e.g. in a singleton class) and try and reuse it as much as possible?
  • Should I use different connections? If so, at what granularity? One connection per endpoint? One connection per query?
  • What role does connection pooling play in all of this and how do I make use of it?
  • Do I have to worry about concurrent requests?
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