How should I resolve the following error message? (111)Connection refused: AH00957: HTTPS: attempt to connect to 127.0.0.1:5001 (127.0.0.1) failed

As mentioned I am receiving the following error message in my apache logs.

[Sat Jun 22 12:57:53.746190 2019] [proxy:error] [pid 10299:tid 140435221571328] (111)Connection refused: AH00957: HTTPS: attempt to connect to 127.0.0.1:5001 (127.0.0.1) failed
[Sat Jun 22 12:57:53.746228 2019] [proxy:error] [pid 10299:tid 140435221571328] AH00959: ap_proxy_connect_backend disabling worker for (127.0.0.1) for 60s
[Sat Jun 22 12:57:53.746233 2019] [proxy_http:error] [pid 10299:tid 140435221571328] [client myip:65168] AH01114: HTTP: failed to make connection to backend: 127.0.0.1

When deploying with code-pipline I see no error messages.

I have tried all of the following;

• Restarting and rebuilding my application.
• Adjusting the launchSettings.json file in my ASP project.
• Adjusting the ports and enabling / disabling HTTPS redirect in my Program class.
• Adjusting my vhsosts file in apache.

Here are some important files for you to browse;

launchSettings.json

{
  "iisSettings": {
    "windowsAuthentication": false,
    "anonymousAuthentication": true,
    "iisExpress": {
      "applicationUrl": "https://localhost:44335",
      "sslPort": 44335
    }
  },
  "profiles": {
    "IIS Express": {
      "commandName": "IISExpress",
      "launchBrowser": true,
      "environmentVariables": {
        "ASPNETCORE_My_Environment": "1",
        "ASPNETCORE_DETAILEDERRORS": "1",
        "ASPNETCORE_ENVIRONMENT": "Development"
      }
    },
    "ProjectName": {
      "commandName": "Project",
      "launchBrowser": true,
      "applicationUrl": "https://localhost:5001;http://localhost:5000",
      "environmentVariables": {
        "ASPNETCORE_ENVIRONMENT": "Production"
      }
    }
  }
}

/etc/apache2/sites-enabled/000-default.conf

<VirtualHost *:80>
    ProxyPreserveHost On
    ProxyPass "/" "http://127.0.0.1:5000/"
    ProxyPassReverse "/" "http://127.0.0.1:5000/"
</VirtualHost>

/etc/apache2/sites-enabled/000-default-le-ssl.conf

<IfModule mod_ssl.c>
<VirtualHost *:443>
    SSLEngine on
    SSLProxyEngine on

    ProxyPreserveHost On
    ProxyPass "/" "https://127.0.0.1:5001/"
    ProxyPassReverse "/" "https://127.0.0.1:5001/"
    ServerName mydomain.com
    Include /etc/letsencrypt/options-ssl-apache.conf
    SSLCertificateFile /etc/letsencrypt/live/mydomain.com/fullchain.pem
    SSLCertificateKeyFile /etc/letsencrypt/live/mydomain.com/privkey.pem
</VirtualHost>
</IfModule>

Startup.cs

        public void ConfigureServices(IServiceCollection services)
        {
            var logger = _loggerFactory.CreateLogger<Startup>();


            logger.LogInformation($"Environment: {_env.EnvironmentName}");

            // Development service configuration
            if (_env.IsDevelopment())
            {
                logger.LogInformation("Development environment");

                services.Configure<ForwardedHeadersOptions>(options =>
                {
                    options.KnownProxies.Add(IPAddress.Parse("127.0.0.1"));
                });

                services.AddHttpsRedirection(options =>
                {
                    options.RedirectStatusCode = StatusCodes.Status307TemporaryRedirect;
                    options.HttpsPort = 44335;
                });
            }

            // Live Service Config
            if (!_env.IsDevelopment())
            {
                services.AddHttpsRedirection(options =>
                {
                    options.RedirectStatusCode = StatusCodes.Status308PermanentRedirect;
                    options.HttpsPort = 5001;
                });

                services.Configure<ForwardedHeadersOptions>(options =>
                {
                    options.KnownProxies.Add(IPAddress.Parse("127.0.0.1"));
                });

                services.AddHsts(options =>
                {
                    options.Preload = true;
                    options.IncludeSubDomains = true;
                    options.MaxAge = TimeSpan.FromDays(60);
                });

            }

            //lines removed for berevity.
}
        public void Configure(IApplicationBuilder app, IHostingEnvironment env)
        {
            // Dev Envoronments
            if (env.IsDevelopment())
            {
                app.UseDeveloperExceptionPage();
                app.UseHttpsRedirection();
            }

            if (env.IsProduction())
            {
                app.UseExceptionHandler("/Home/Error");
                app.UseHsts();

                app.UseForwardedHeaders(new ForwardedHeadersOptions
                {
                    ForwardedHeaders = ForwardedHeaders.XForwardedFor | ForwardedHeaders.XForwardedProto
                });
            }


            app.UseHttpsRedirection();
            //lines removed for berevity.
}

If you need any more information please let me know.

EDIT: Server: EC2 Ubuntu (Build via Code Star), Web service: Apache, Project Code: asp.net core 2.1, SSL Certificates: LetsEncrypt, Proxy: Not 100% sure.