Possible side effect using comma in querystring?

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I'd like to use , in URL querystring value but it is reserved character. However, we can see many e-commerce sites give comma-galore querystring urls in these days.

What do we consider when we use , in querystring? Should it be encoded as %2c always?

Note that my server-side frameworks are ASP.NET WebApi, dJango, and Node.js.

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