Is running Umbraco within an ASP.NET Core API possible?

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Is it possible to utilize Umbraco with an ASP.NET Core API project? Can these two techs work together or do I have to use .NET 4.x ?

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I accepted @mortenbock's answer, but I strongly suggest to people interested in this question to also read the comments below, where @Tseng has provided some very useful answers.

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