How to chose minimum and target versions of Windows 10 SDK

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There are several Windows UWP SDKs available here. I want to start developing a UWP app and its bit confusing for me to chose an SDK version. If I use an SDK like Windows 10 SDK (10586) does that mean my app only works with Windows 10 OS build 10586 and above? and will not works with Windows 10 OS build 10240?

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