CharInSet is much slower than IN, should I fix W1050 warning hint?

I use IN a lot in my project and I have lots of these warnings:

[DCC Warning] Unit1.pas(40): W1050 WideChar reduced to byte char in set expressions. Consider using CharInSet function in SysUtils unit.

I made a quick test and using CharInSet instead of IN is from 65%-100% slower:

if s1[i] in ['A', 'B', 'C', 'D', 'E', 'F', 'G', 'H', 'I', 'J', 'K', 'L', 'M', 'N', 'O', 'P', 'Q', 'R', 'S', 'T', 'U', 'V', 'W', 'X', 'Y', 'Z'] then

vs

if CharInSet(s1[i], ['A', 'B', 'C', 'D', 'E', 'F', 'G', 'H', 'I', 'J', 'K', 'L', 'M', 'N', 'O', 'P', 'Q', 'R', 'S', 'T', 'U', 'V', 'W', 'X', 'Y', 'Z']) then

Here is code for 2 tests, one works with loop through shorter strings, one loops once through a large string:

Adding 2 buttons on form I tested this for short string:

procedure TForm1.Button1Click(Sender: TObject);
var s1: string;
  t1, t2: TStopWatch;
  a, i, cnt, vMaxLoop: Integer;
begin
  s1 := '[DCC Warning] Unit1.pas(40): W1050 WideChar reduced to byte char in set expressions.  Consider using CharInSet function in SysUtils unit.';
  vMaxLoop := 10000000;

  cnt := 0;
  t1 := TStopWatch.Create;
  t1.Start;
  for a := 1 to vMaxLoop do
    for i := 1 to Length(s1) do
      if s1[i] in ['A', 'B', 'C', 'D', 'E', 'F', 'G', 'H', 'I', 'J', 'K', 'L', 'M', 'N', 'O', 'P', 'Q', 'R', 'S', 'T', 'U', 'V', 'W', 'X', 'Y', 'Z'] then
        inc(cnt);
  t1.Stop;

  cnt := 0;
  t2 := TStopWatch.Create;
  t2.Start;
  for a := 1 to vMaxLoop do
    for i := 1 to Length(s1) do
      if CharInSet(s1[i], ['A', 'B', 'C', 'D', 'E', 'F', 'G', 'H', 'I', 'J', 'K', 'L', 'M', 'N', 'O', 'P', 'Q', 'R', 'S', 'T', 'U', 'V', 'W', 'X', 'Y', 'Z']) then
        inc(cnt);
  t2.Stop;

  Button1.Caption := inttostr(t1.ElapsedMilliseconds) + ' - ' + inttostr(t2.ElapsedMilliseconds);
end;

And this for 1 long string:

procedure TForm1.Button2Click(Sender: TObject);
var s1: string;
  t1, t2: TStopWatch;
  a, i, cnt, vMaxLoop: Integer;
begin

  s1 := '[DCC Warning] Unit1.pas(40): W1050 WideChar reduced to byte char in set expressions.  Consider using CharInSet function in SysUtils unit.';
  s1 := DupeString(s1, 1000000);
  s1 := s1 + s1 + s1 + s1; // DupeString is limited, use this to create longer string

  cnt := 0;
  t1 := TStopWatch.Create;
  t1.Start;
  for i := 1 to Length(s1) do
    if s1[i] in ['A', 'B', 'C', 'D', 'E', 'F', 'G', 'H', 'I', 'J', 'K', 'L', 'M', 'N', 'O', 'P', 'Q', 'R', 'S', 'T', 'U', 'V', 'W', 'X', 'Y', 'Z'] then
      inc(cnt);
  t1.Stop;

  cnt := 0;
  t2 := TStopWatch.Create;
  t2.Start;
  for i := 1 to Length(s1) do
    if CharInSet(s1[i], ['A', 'B', 'C', 'D', 'E', 'F', 'G', 'H', 'I', 'J', 'K', 'L', 'M', 'N', 'O', 'P', 'Q', 'R', 'S', 'T', 'U', 'V', 'W', 'X', 'Y', 'Z']) then
      inc(cnt);
  t2.Stop;

  Button2.Caption := inttostr(t1.ElapsedMilliseconds) + ' - ' + inttostr(t2.ElapsedMilliseconds);
end;

Why do they recommend slower option, or how can I fix this warning without penalty in performance?