Why are the the vertical and horizontal center alignments greyed out?
I know it`s been a while since this question has been asked, but in case someone is still stuck with this problem: If "Add Constrains" is greyed out like in the screenshot above, check the Layout-Settings. Layout should be Inferred (Constrains). Once you change this setting from Autoresizing mask to Inferred (Constrains), the "Add Constrains"-Button is selectable. change the Layout-Setting