Optimizing Bitwise Logic

In my code the following lines are currently the hotspot:

int table1[256] = /*...*/;
int table2[512] = /*...*/;
int table3[512] = /*...*/;

int* result = /*...*/;
for(int r = 0; r < r_end; ++r)
{
    std::uint64_t bits = bit_reader.value(); // 64 bits, no assumption regarding bits.

    // The get_ functions are table lookups from the highest word of the bits variable.

    struct entry
    {
        int sign_offset : 5;
        int r_offset    : 4;        
        int x           : 7;        
    };

    // NOTE: We are only interested in the highest word in the bits variable.

    entry e;
    if(is_in_table1(bits)) // branch prediction should work well here since table1 will be hit more often than 2 or 3, and 2 more often than 3.
        e = reinterpret_cast<const entry&>(table1[get_table1_index(bits)]);
    else if(is_in_table2(bits))
        e = reinterpret_cast<const entry&>(table2[get_table2_index(bits)]);
    else
        e = reinterpret_cast<const entry&>(table3[get_table3_index(bits)]);

    r                 += e.r_offset; // r is 18 bits, top 14 bits are always 0.
    int x              = e.x; // x is 14 bits, top 18 bits are always 0.        
    int sign_offset    = e.sign_offset;

    assert(sign_offset <= 16 && sign_offset > 0);

    // The following is the hotspot.

    int sign    = 1 - (bits >> (63 - sign_offset) & 0x2);
    (*result++) = ((x << 18) * sign) | r; // 32 bits

    // End of hotspot

    bit_reader.skip(sign_offset); // sign_offset is the last bit used.
}

Though I haven't figured out how to further optimize this, maybe something from intrinsics for Operations at Bit-Granularity, __shiftleft128 or _rot could be useful?

Note that I am also doing processing of the resulting data on the GPU, so the important thing is to get something into result which the GPU then can use to calculate the correct.

Suggestions?

EDIT:

Added table look-up.

EDIT:

            int sign = 1 - (bits >> (63 - e.sign_offset) & 0x2);
000000013FD6B893  and         ecx,1Fh  
000000013FD6B896  mov         eax,3Fh  
000000013FD6B89B  sub         eax,ecx  
000000013FD6B89D  movzx       ecx,al  
000000013FD6B8A0  shr         r8,cl  
000000013FD6B8A3  and         r8d,2  
000000013FD6B8A7  mov         r14d,1  
000000013FD6B8AD  sub         r14d,r8d