How do I extract the last two items from the list, strings or tuples in Python?

User will input the string, list or tuples.

I have to extract the first do and the last two values. For the first two values:

ls[:2]

For the last two values how can I do it?

If n is the total number of values the last two item can be sliced as:

[n-1:]

How can I put down in the code?