Best practices for developing larger JavaScript applications

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Having a strong background in Java/C++ i wonder if it is possible to develop a somewhat larger JavaScript application without having to cut back on quality.

Any hints are appreciated regarding:

  • Development Enviroment
  • Debugging Techniques
  • Unit Testing
  • Profiling
  • Instrumentation
  • System Design
  • Interface Design
  • Code Design

I'm also curious how projects like JavaScript PC Emulator and JavaScript Game Engine handled those issues in case some of you know.

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