How can I use HTML + Javascript to build a python GUI?

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I have been experimenting with Appcelerator Titanum yesterday and I think it's cool when it comes to Javascript.

Python features on Appcelerator Titanum are so limited (can't use some modules for example).

My question is How can I use html & javascript as a GUI tool for a real python application ?

I am running windows 7 and i was thinking of using webkit for that purpose but couldn't know how to work with it in python.

I am planning to make a standalone executable using py2exe as I don't know if the users always have python and the appropriate modules installed.

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