#if DEBUG vs. Conditional("DEBUG")

This one can be useful as well:

if (Debugger.IsAttached)
{
...
}

Usually you would need it in Program.cs where you want to decide to run either Debug on Non-Debug code and that too mostly in Windows Services. So I created a readonly field IsDebugMode and set its value in static constructor as shown below.

static class Program
{

    #region Private variable
    static readonly bool IsDebugMode = false;
    #endregion Private variable

    #region Constrcutors
    static Program()
    {
 #if DEBUG
        IsDebugMode = true;
 #endif
    }
    #endregion

    #region Main

    /// <summary>
    /// The main entry point for the application.
    /// </summary>
    static void Main(string[] args)
    {

        if (IsDebugMode)
        {
            MyService myService = new MyService(args);
            myService.OnDebug();             
        }
        else
        {
            ServiceBase[] services = new ServiceBase[] { new MyService (args) };
            services.Run(args);
        }
    }

    #endregion Main        
}