What does isa mean in objective-c?

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I would like to know the meaning of the below written lines with an example. I'm unable to understand what the lines actually mean. The lines are from google's objective-c coding guidelines.

Initialization
Don't initialize variables to 0 or nil in the init method; it's redundant.

All memory for a newly allocated object is initialized to 0 (except for isa), so don't clutter up the init method by re-initializing variables to 0 or nil.

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