MongoDB on EC2 server or AWS SimpleDB?

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What scenario makes more sense - host several EC2 instances with MongoDB installed, or much rather use the Amazon SimpleDB webservice?

When having several EC2 instances with MongoDB I have the problem of setting the instance up by myself.

When using SimpleDB I have the problem of locking me into Amazons data structure right?

What differences are there development-wise? Shouldn't I be able to just switch the DAO of my service layers, to either write to MongoDB or AWS SimpleDB?

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