Example using BLOB in SQLAlchemy

Why don't you use LargeBinary?

Extract from: https://docs.sqlalchemy.org/en/13/core/type_basics.html#sqlalchemy.types.LargeBinary

class sqlalchemy.types.LargeBinary(length=None)
A type for large binary byte data.

The LargeBinary type corresponds to a large and/or unlengthed binary type for the target platform, such as BLOB on MySQL and BYTEA for PostgreSQL. It also handles the necessary conversions for the DBAPI.

I believe this might assist you.