Can XMLHttpRequest send a request to http://mydomain.example:81/ from http://mydomain.example/?
Can XMLHttpRequest send a request to http://mydomain.example:81/ from http://mydomain.example/?
For two documents to be considered to have the same origin, the protocol (http/https), the domain and the port (the default 80 or :xx) have to be indentical. So no, you cannot use xhr against a different port.