I am trying to delete files in my $(TargetDir) within visual studio before building a project.
How do you have to format command line to get around this problem I am getting below?

I am trying to delete files in my $(TargetDir) within visual studio before building a project.
How do you have to format command line to get around this problem I am getting below?

Try
cd $(TargetDir)
del *.tif
As jvenema pointed out, your $(TargetDir) is expanding into a path containing spaces in the folder names which is breaking the delete command.
For DOTNET Core, your quotes need to be escaped, like this:
<Target Name="PreBuild" BeforeTargets="PreBuildEvent">
<Exec Command="del "$(ProjectDir)wwwroot\_framework\*.*" /q" />
</Target>
<Target Name="PostBuild" AfterTargets="PostBuildEvent">
<Exec Command="copy "$(ProjectDir)..\Client\bin\Debug\net5.0\wwwroot\_framework\*.*" "$(ProjectDir)wwwroot\_framework\"" />
</Target>