How to detect if my application is running in a virtual machine?

According to Virtual PC Guy's blog post "Detecting Microsoft virtual machines", you can use WMI to check the manufacturer of the motherboard. In PowerShell:

 (gwmi Win32_BaseBoard).Manufacturer -eq "Microsoft Corporation"

Remember you should not just check popular VM model,manufacturer name from wmi, You should also check difference between reality and virtualization.
VM don't have much features.
1) check-if-cpu-temperature-information-is-available

wmic /namespace:\\root\WMI path MSAcpi_ThermalZoneTemperature get CurrentTemperature
//On Real PC
//CurrentTemperature
//3147

//On VM
//Node - Admin
//Error:
//Description not supported

Tested on vmware,virtualbox,windows server,app.any.run sandbox.

2) Win32_PortConnector

Get-WmiObject Win32_PortConnector
//On Vm it is null

//On real pc it looks something like that
Tag                         : Port Connector 0
ConnectorType               : {23, 3}
SerialNumber                :
ExternalReferenceDesignator :
PortType                    : 2

I have tested for 3 types - VirtualBox,Wmware and Huper-V

foreach (var mo in "Select * from Win32_ComputerSystem")
{
    var model = (string)mo["Model"];

    if (model == "VirtualBox" ||
        model == "Virtual Machine" ||
        model.StartsWith("VMware"))
    {
        return true;
    }
}
return false;

I wanted to make this configurable so I converted @RobSiklos answer to a WMI query. Now I can put the query in a config location and change it when needed.

private static bool IsVirtual()
{
    using (var searcher = new System
        .Management
        .ManagementObjectSearcher(@"SELECT * from Win32_ComputerSystem 
                                    WHERE (Manufacturer LIKE '%microsoft corporation%' AND Model LIKE '%virtual%')
                                    OR Manufacturer LIKE '%vmware%'
                                    OR Model LIKE '%VirtualBox%'"))
    {
        using (System.Management.ManagementObjectCollection items = searcher.Get())
        {
            if (items.Count > 0)
            {
                return true;
            }
        }
    }

    return false;
}

WQL Reference:

https://docs.microsoft.com/en-us/windows/win32/wmisdk/wql-sql-for-wmi