Automate excel worksheet in a share point using python

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I have this live excel worksheet in share point. I want to update the contents of the file in that excel sheet using data scraped from a website. So I am done with the data scraping part.

Things I wanted to do:

Getting into sharepoint and opening the particular excel sheet link to update it

In excel worksheet. It has 8 columns. I wanted to update only 6 columns. Rest of the 2 columns should be untouched

I wanted to know how to make these above 2 things happen. A little guidance would be helpful

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