You can use the Grabcut [1] algorithm to extract a segment from a bounding-box.
Grabcut tries to cluster the pixels into two groups, outside of the bounding-box and inside, while penalizing label disagreement with adjacent pixels with a similar color.
For example:
import cv2
import numpy as np
im = cv2.imread('beef.jpg')
mask = np.zeros(im.shape[:2], np.uint8)
bgd_model = np.zeros((1, 65), np.float64)
fgd_model = np.zeros((1, 65), np.float64)
rect = (30, 25, 30 + 318, 25 + 350) # (x, y, w, h)
cv2.grabCut(im, mask, rect, bgd_model, fgd_model, 10, cv2.GC_INIT_WITH_RECT)
mask = np.where((mask == cv2.GC_BGD) | (mask == cv2.GC_PR_BGD), 0, 1).astype(np.uint8)
contour, _= cv2.findContours(mask, cv2.RETR_EXTERNAL, cv2.CHAIN_APPROX_SIMPLE)
cv2.drawContours(im, contour, -1, (0, 255, 0))
cv2.imwrite("output.png", im)

[1] Rother, Carsten, Vladimir Kolmogorov, and Andrew Blake. " GrabCut" interactive foreground extraction using iterated graph cuts." ACM Transactions on Graphics (TOG) 23.3 (2004): 309-314.