Taken from Microsoft Technet.

Redirecting Web Sites in IIS 6.0 (IIS 6.0)

When a browser requests a page or program on your Web site, the Web server locates the page identified by the URL and returns it to the browser. When you move a page on your Web site, you can't always correct all of the links that refer to the old URL of the page. To make sure that browsers can find the page at the new URL, you can instruct the Web server to redirect the browser to the new URL.

You can redirect requests for files in one directory to a different directory, to a different Web site, or to another file in a different directory. When the browser requests the file at the original URL, the Web server instructs the browser to request the page by using the new URL.

Important

You must be a member of the Administrators group on the local computer to perform the following procedure or procedures. As a security best practice, log on to your computer by using an account that is not in the Administrators group, and then use the runas command to run IIS Manager as an administrator. At a command prompt, type runas /user:Administrative_AccountName "mmc %systemroot%\system32\inetsrv\iis.msc".

Procedures

To redirect requests to another Web site or directory

1. In IIS Manager, expand the local computer, right-click the Web site or directory you want to redirect, and click Properties.

2. Click the Home Directory, Virtual Directory, or Directory tab.

3. Under The content for this source should come from, click A redirection to a URL.

4. In the Redirect to box, type the URL of the destination directory or Web site. For example, to redirect all requests for files in the Catalog directory to the NewCatalog directory, type /NewCatalog.
   

To redirect all requests to a single file

1. In IIS Manager, expand the local computer, right-click the Web site or directory you want to redirect, and click Properties.

2. Click the Home Directory, Virtual Directory, or Directory tab.

3. Under The content for this source should come from, click A redirection to a URL.

4. In the Redirect to box, type the URL of the destination file.

5. Select the The exact URL entered above check box to prevent the Web server from appending the original file name to the destination URL.

   You can use wildcards and redirect variables in the destination URL to precisely control how the original URL is translated into the destination URL.

   You can also use the redirect method to redirect all requests for files in a particular directory to a program. Generally, you should pass any parameters from the original URL to the program, which you can do by using redirect variables.
   

   To redirect requests to a program

   
   

6. In IIS Manager, expand the local computer, right-click the Web site or directory you want to redirect, and click Properties.

7. Click the Home Directory, Virtual Directory, or Directory tab.

8. Under The content for this source should come from, click A redirection to a URL.

   In the Redirect to box, type the URL of the program, including any redirect variables needed to pass parameters to the program. For example, to redirect all requests for scripts in a Scripts directory to a logging program that records the requested URL and any parameters passed with the URL, type /Scripts/Logger.exe?URL=$V+PARAMS=$P. $V and $P are redirect variables.

9. Select the The exact URL entered above check box to prevent the Web server from appending the original file name to the destination URL.

If you have loads of re-directs to create, having loads of virtual directories over the places is a nightmare to maintain. You could try using ISAPI redirect an IIS extension. Then all you re-directs are managed in one place.

http://www.isapirewrite.com/docs/

It allows also you to match patterns based on reg ex expressions etc. I've used where I've had to re-direct 100's of pages and its saved a lot of time.

Here's the config for ISAPI_Rewrite 3:

RewriteBase /

RewriteCond %{HTTP_HOST} ^mysite.org.uk$ [NC]

RewriteRule ^stuff/(.+)$ http://stuff.mysite.org.uk/$1 [NC,R=301,L]